S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hrd1p
Description	Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
GO Terms: Biological Process	level 4: endoplasmic reticulum unfolded protein response level 5: fungal-type cell wall organization level 6: retrograde protein transport, ER to cytosol level 7: ubiquitin-dependent ERAD pathway level 8: ubiquitin-dependent protein catabolic process level 8: protein ubiquitination level 9: protein autoubiquitination
GO Terms: Molecular Function	level 3: transferase activity level 5: ubiquitin-protein transferase activity level 5: metal ion binding level 6: ubiquitin protein ligase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: membrane level 4: endoplasmic reticulum level 4: integral component of membrane level 5: endoplasmic reticulum membrane level 5: Hrd1p ubiquitin ligase complex level 6: Hrd1p ubiquitin ligase ERAD-L complex level 6: Hrd1p ubiquitin ligase ERAD-M complex
External source	Open in SGD