S.cerevisiae - Yeastract

Regulation Reference(s)

The Yeastract team, is actively curating each regulation evidence code, association type and environmental condition.

Transcription Factor	Target ORF/Genes	References	Evidence Code	Evidence Experiment	Association Type	Strain	Environmental Group	Environmental Condition	Log2FC
Rap1p	YPL111W	PubMed Kovari LZ et al., Journal of bacteriology, 1993 Feb;175(4):941-51	Direct	lacZ - wt vs mutant promoter sequence	Positive	S288c	Unstressed log-phase growth (control)	Minimal medium; mid-log phase	N/A
		PubMed Jorgensen MU et al., Current genetics, 1997 Mar;31(3):241-7	Indirect	Enzyme activity - wt vs mutant promoter sequence	Positive	S288c	Unstressed log-phase growth (control)	cells grown on ammonia (basal, repressing conditions)	N/A
		PubMed Lieb JD et al., Nature genetics, 2001 Aug;28(4):327-34	Direct	Chip-on-chip	N/A	S288c	N/A	N/A	N/A
		PubMed Lee TI et al., Science (New York, N.Y.), 2002 Oct 25;298(5594):799-804	Direct	Chip-on-chip	N/A	S288c	Unstressed log-phase growth (control)	YPD medium; mid-log phase	N/A
		PubMed Kasahara K et al., Molecular and cellular biology, 2007 Oct;27(19):6686-705	Direct	Chip-on-chip	N/A	S288c	Unstressed log-phase growth (control)	YPD	N/A
		PubMed Lavoie H et al., PLoS biology, 2010 Mar 9;8(3):e1000329	Direct	Chip-on-chip	N/A	S288c	Unstressed log-phase growth (control)	YPD	N/A
		PubMed Reimand J et al., Nucleic acids research, 2010 Aug;38(14):4768-77	Indirect	Microarray analysis - WT vs TF Deletion	Positive	BY4741; S288C; R1158	Unstressed log-phase growth (control)	Standard YPD conditions Dataset ewxtracted from The Longhorn Array Database (LAD). Transcription factor gene deletion.	1.017792272669
		PubMed Lickwar CR et al., Nature, 2012 Apr 11;484(7393):251-5	Direct	ChIP	N/A	S288c	Cell cycle/morphology	Cells arrested at G1 phase with alpha-factor cultivated in 2% Galactose YP medium	N/A
		PubMed Rossi MJ et al., Nature, 2021 Apr;592(7853):309-314	Direct	ChIP-exo	N/A	BY4741	Unstressed log-phase growth (control)	YPD medium, 25.C	N/A
		PubMed Byun JY et al., Microbial cell factories, 2025 Feb 24;24(1):47	Indirect	RNA-seq - wt vs TF overexpression	Negative	CEN.PK2-1D	Carbon source quality/availability	YPD medium (15h) (diauxic shift)	-2.84486998791949
			Indirect	RNA-seq - wt vs TF overexpression	Negative	CEN.PK2-1D	Carbon source quality/availability	YPD medium (36h) (post-diauxic shift)	-1.38372546691267
			Indirect	RNA-seq - wt vs TF overexpression	Negative	CEN.PK2-1D	Unstressed log-phase growth (control)	YPD medium (9h) control	-1.45783796934426
			Indirect	RNA-seq analysis - TF Over-expression vs WT	Negative	cen.pk-2-1C	Unstressed log-phase growth (control)	RNA extraction at 15h. Medium: YPD (1% yeast extract, 2% peptone, 2% glucose) or synthetic complete (SC) medium supplemented as required for auxotrophic markers. Temperature: 30°C, aerobic shaking. Growth phase: exponential or stationary phase.	-7.18441151264258
			Indirect	RNA-seq analysis - TF Over-expression vs WT	Negative	cen.pk-2-1C	Carbon source quality/availability	RNA extraction at 36h. Medium: YPD (1% yeast extract, 2% peptone, 2% glucose) or synthetic complete (SC) medium supplemented as required for auxotrophic markers. Temperature: 30°C, aerobic shaking. Growth phase: exponential or stationary phase.	-2.60941329808426
			Indirect	RNA-seq analysis - TF Over-expression vs WT	Negative	cen.pk-2-1C	Unstressed log-phase growth (control)	RNA extraction at 9h. Medium: YPD (1% yeast extract, 2% peptone, 2% glucose) or synthetic complete (SC) medium supplemented as required for auxotrophic markers. Temperature: 30°C, aerobic shaking. Growth phase: exponential or stationary phase.	-2.74696393501405