S.cerevisiae - Yeastract

Modelling prediction
Essentiality
[metab] Optimisation
manipulating gene expression
manipulating TF expression
Cross species
Promoter analysis
Homologous network
Network comparison
Rank by Unique TFBS
Rank genes
Rank by TF
Rank by GO
Regulatory Associations
Search for TFs
Search for Genes
Search for Associations
Pattern Matching
Search by DNA Motif
Find TF Binding Site(s)
Utilities
Search for Orthologs
IUPAC Code Generation
ORF List ⇔ Gene List
Retrieve
TF-Consensus List
Regulation Matrix
Upstream Sequence
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Predict [metabolite] optimisation by manipulating TF expression

Considering the metabolic model/medium:
Model:
Medium:

Rank TFs by:

Maximize the production of metabolite (exchange reaction):

Considering TF documented regulations with:
Expression evidence
TF acting as activator
TF acting as inhibitor
DNA binding and expression evidence