S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Drs2p
Description	Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease
GO Terms: Biological Process	level 5: intracellular protein transport level 6: endocytosis level 6: phospholipid transport level 6: endocytic recycling level 6: phospholipid translocation level 7: aminophospholipid translocation level 7: post-Golgi vesicle-mediated transport level 7: response to pheromone triggering conjugation with cellular fusion
GO Terms: Molecular Function	level 3: ATP hydrolysis activity level 3: ATPase-coupled intramembrane lipid transporter activity level 4: nucleotide binding level 6: phosphatidylcholine flippase activity level 6: phosphatidylserine flippase activity level 6: magnesium ion binding level 6: ATP binding level 6: phosphatidylethanolamine flippase activity
GO Terms: Cellular Component	level 3: membrane level 4: integral component of membrane level 4: endoplasmic reticulum level 4: Golgi apparatus level 4: plasma membrane level 5: Cdc50p-Drs2p complex level 5: trans-Golgi network
External source	Open in SGD