S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Scs22p
Description	Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PM PI4P levels by controlling access of the Sac1p phosphatase to its substrate, PI4P; human VAP homolog; similar to D. melanogaster inturned protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; SCS22 has a paralog, SCS2, that arose from the whole genome duplication
GO Terms: Biological Process	level 5: phospholipid biosynthetic process level 5: endoplasmic reticulum-plasma membrane tethering level 6: regulation of phosphatidylinositol dephosphorylation level 6: endoplasmic reticulum membrane organization level 7: reticulophagy
GO Terms: Molecular Function	level 1: molecular_function level 5: FFAT motif binding
GO Terms: Cellular Component	level 3: membrane level 3: cytosol level 4: integral component of membrane level 4: plasma membrane level 5: endoplasmic reticulum membrane
External source	Open in SGD