S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ist2p
Description	Cortical ER protein involved in ER-plasma membrane (PM) tethering; one of 6 proteins (Ist2, Scs2, Scs22, Tcb1, Tcb2, Tcb3) that connect ER to PM, regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1 phosphatase to PI4P; required to locate Osh6, Osh7 in ER/PM contact site to allow phosphatidylserine transport from ER to PM; localizes to mother in small-budded cells, to bud in medium-, large-budded cells; mRNA transported to bud tip by actomyosin-driven process
GO Terms: Biological Process	level 3: transmembrane transport level 6: regulation of phosphatidylinositol dephosphorylation level 6: protein localization to plasma membrane level 6: endoplasmic reticulum membrane organization level 7: chloride transmembrane transport
GO Terms: Molecular Function	level 3: lipid binding level 7: chloride channel activity
GO Terms: Cellular Component	level 3: cellular bud membrane level 3: cell periphery level 3: membrane level 4: integral component of membrane level 4: plasma membrane level 5: cortical endoplasmic reticulum
External source	Open in SGD