S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Npl4p
Description	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
GO Terms: Biological Process	level 5: protein transport level 5: mitotic spindle disassembly level 6: mRNA transport level 6: retrograde protein transport, ER to cytosol level 6: DNA replication termination level 7: protein localization to vacuole level 7: positive regulation of protein localization to nucleus level 7: proteasome-mediated ubiquitin-dependent protein catabolic process level 7: ubiquitin-dependent ERAD pathway level 7: negative regulation of telomerase activity level 7: cytoplasm protein quality control by the ubiquitin-proteasome system level 7: ER-associated misfolded protein catabolic process level 8: ubiquitin-dependent protein catabolic process level 8: mitochondria-associated ubiquitin-dependent protein catabolic process level 8: ribosome-associated ubiquitin-dependent protein catabolic process level 9: nonfunctional rRNA decay
GO Terms: Molecular Function	level 5: ubiquitin binding level 6: K48-linked polyubiquitin modification-dependent protein binding level 6: ubiquitin protein ligase binding level 7: zinc ion binding
GO Terms: Cellular Component	level 3: membrane level 3: RQC complex level 3: perinuclear region of cytoplasm level 3: cytoplasm level 4: nuclear outer membrane-endoplasmic reticulum membrane network level 4: replisome level 4: endoplasmic reticulum level 4: VCP-NPL4-UFD1 AAA ATPase complex level 5: Doa10p ubiquitin ligase complex level 5: nucleus level 5: nuclear membrane level 5: endoplasmic reticulum membrane level 5: Cdc48p-Npl4p-Vms1p AAA ATPase complex level 6: Hrd1p ubiquitin ligase ERAD-L complex
External source	Open in SGD