S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Der1p
Description	ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1
GO Terms: Biological Process	level 4: endoplasmic reticulum unfolded protein response level 5: protein transport level 6: misfolded protein transport level 6: retrograde protein transport, ER to cytosol level 7: ubiquitin-dependent ERAD pathway
GO Terms: Molecular Function	level 4: misfolded protein binding
GO Terms: Cellular Component	level 3: membrane level 4: endoplasmic reticulum level 4: integral component of membrane level 5: endoplasmic reticulum membrane level 6: Hrd1p ubiquitin ligase ERAD-L complex level 6: integral component of endoplasmic reticulum membrane
External source	Open in SGD