S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Pdi1p
Description	Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, processing of non-native disulfide bonds; Ero1p activator; complexes with exomannosidase, Mnl1p to facilitate the recognition of misfolded glycoproteins and the trimming of glycan Man8GlcNAc2 to Man7GlcNAc2 on substrates, thereby accelerating ERAD; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
GO Terms: Biological Process	level 3: protein folding level 5: response to endoplasmic reticulum stress level 7: mannose trimming involved in glycoprotein ERAD pathway level 8: protein alpha-1,2-demannosylation
GO Terms: Molecular Function	level 3: protein binding level 3: isomerase activity level 4: unfolded protein binding level 4: protein disulfide isomerase activity level 4: protein-disulfide reductase activity
GO Terms: Cellular Component	level 3: endoplasmic reticulum quality control compartment level 4: endoplasmic reticulum level 5: endoplasmic reticulum lumen
External source	Open in SGD