S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Slx5p
Description	Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex; role in Ub-mediated degradation of histone variant Cse4p preventing mislocalization to euchromatin; role in proteolysis of spindle positioning protein Kar9p, and DNA repair proteins Rad52p and Rad57p; forms SUMO-dependent nuclear foci, including DNA repair centers; contains a RING domain and two SIM motifs; associates with the centromere; required for maintenance of genome integrity like human ortholog RNF4
GO Terms: Biological Process	level 5: apoptotic process level 5: cellular response to DNA damage stimulus level 6: DNA repair level 6: telomere maintenance level 8: ubiquitin-dependent protein catabolic process level 8: protein ubiquitination level 8: protein sumoylation
GO Terms: Molecular Function	level 3: transferase activity level 5: SUMO binding level 5: ubiquitin-protein transferase activity
GO Terms: Cellular Component	level 4: chromosome, centromeric region level 4: kinetochore level 5: SUMO-targeted ubiquitin ligase complex level 5: nucleus level 5: chromosome
External source	Open in SGD