S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sir2p
Description	Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy
GO Terms: Biological Process	level 4: establishment of protein-containing complex localization to telomere level 4: regulation of DNA stability level 4: sister chromatid cohesion level 5: regulation of mating type switching level 5: chromatin organization level 5: cellular response to DNA damage stimulus level 6: DNA repair level 6: rDNA heterochromatin formation level 6: telomere tethering at nuclear periphery level 8: double-strand break repair via nonhomologous end joining level 8: subtelomeric heterochromatin formation level 8: negative regulation of DNA replication level 8: negative regulation of DNA recombination level 9: negative regulation of DNA amplification level 10: silent mating-type cassette heterochromatin formation
GO Terms: Molecular Function	level 3: transferase activity level 4: nucleosome binding level 4: protein lysine deacetylase activity level 5: NAD+ binding level 5: metal ion binding level 6: NAD-dependent histone deacetylase activity level 7: NAD-dependent histone deacetylase activity (H3-K14 specific) level 7: zinc ion binding level 7: NAD-dependent histone deacetylase activity (H3-K9 specific) level 7: NAD-dependent histone deacetylase activity (H4-K16 specific) level 8: DNA replication origin binding
GO Terms: Cellular Component	level 4: chromosome, telomeric region level 4: heterochromatin level 4: chromatin silencing complex level 5: RENT complex level 5: nucleus level 5: nucleolus
External source	Open in SGD