S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Vam6p
Description	Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles
GO Terms: Biological Process	level 4: autophagy level 4: regulation of catalytic activity level 4: vesicle tethering level 5: protein transport level 5: vesicle-mediated transport level 5: intracellular protein transport level 6: vacuole organization level 6: piecemeal microautophagy of the nucleus level 7: endosomal vesicle fusion level 7: regulation of SNARE complex assembly level 8: vacuole fusion, non-autophagic level 9: positive regulation of TORC1 signaling
GO Terms: Molecular Function	level 5: phosphatidylinositol binding level 6: guanyl-nucleotide exchange factor activity level 6: small GTPase binding
GO Terms: Cellular Component	level 3: membrane level 3: cytoplasm level 4: vacuole-mitochondrion membrane contact site level 4: HOPS complex level 4: vacuole level 5: vacuolar membrane level 6: fungal-type vacuole level 7: fungal-type vacuole membrane
External source	Open in SGD