S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Pph22p
Description	Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph21p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
GO Terms: Biological Process	level 5: G1/S transition of mitotic cell cycle level 6: negative regulation of ribonucleoprotein complex localization level 7: regulation of translation level 8: regulation of TORC1 signaling level 8: positive regulation of autophagosome assembly
GO Terms: Molecular Function	level 3: hydrolase activity level 4: phosphoprotein phosphatase activity level 5: metal ion binding level 5: protein serine/threonine phosphatase activity level 6: myosin phosphatase activity
GO Terms: Cellular Component	level 3: nuclear periphery level 3: cytoplasm level 5: condensed chromosome, centromeric region level 5: nucleus
External source	Open in SGD