S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Gis1p
Description	Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
GO Terms: Biological Process	level 6: chromatin remodeling level 7: regulation of phospholipid biosynthetic process level 9: negative regulation of transcription by RNA polymerase II level 9: positive regulation of transcription by RNA polymerase II
GO Terms: Molecular Function	level 5: histone demethylase activity level 5: DNA-binding transcription repressor activity, RNA polymerase II-specific level 5: metal ion binding level 5: DNA-binding transcription activator activity, RNA polymerase II-specific level 5: DNA binding level 6: histone H3-methyl-lysine-9 demethylase activity level 6: histone H3-methyl-lysine-36 demethylase activity level 7: zinc ion binding level 8: RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO Terms: Cellular Component	level 3: cytosol level 4: mitochondrion level 5: nucleus
External source	Open in SGD