S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hst4p
Description	NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3
GO Terms: Biological Process	level 6: cellular response to biotin starvation level 6: short-chain fatty acid metabolic process level 7: regulation of DNA repair level 8: mRNA transcription level 8: ncRNA transcription level 8: pericentric heterochromatin formation level 8: subtelomeric heterochromatin formation level 9: replication-born double-strand break repair via sister chromatid exchange level 9: negative regulation of transcription by RNA polymerase II level 9: histone H3-K56 deacetylation
GO Terms: Molecular Function	level 3: transferase activity level 4: protein lysine deacetylase activity level 5: metal ion binding level 5: NAD+ binding level 6: NAD-dependent histone deacetylase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: cytoplasm level 4: chromosome, telomeric region level 4: mitochondrion level 5: mating-type region heterochromatin level 5: nucleus
External source	Open in SGD