S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mus81p
Description	Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p
GO Terms: Biological Process	level 3: meiotic cell cycle level 4: reciprocal meiotic recombination level 5: cellular response to DNA damage stimulus level 5: resolution of meiotic recombination intermediates level 6: DNA recombination level 6: nucleic acid phosphodiester bond hydrolysis level 6: mitotic intra-S DNA damage checkpoint signaling level 6: DNA topological change level 6: DNA repair level 6: negative regulation of helicase activity level 7: double-strand break repair level 7: DNA catabolic process, endonucleolytic level 9: double-strand break repair via break-induced replication
GO Terms: Molecular Function	level 3: hydrolase activity level 4: enzyme inhibitor activity level 5: DNA binding level 5: nuclease activity level 5: metal ion binding level 6: endonuclease activity level 6: endodeoxyribonuclease activity level 8: crossover junction endodeoxyribonuclease activity level 8: 3'-flap endonuclease activity
GO Terms: Cellular Component	level 5: nucleus level 6: Holliday junction resolvase complex
External source	Open in SGD