S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Npl3p
Description	RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; required for pre-mRNA splicing; interacts with E3 ubiquitin ligase Bre1p, linking histone ubiquitination to mRNA processing; may have role in telomere maintenance; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in cytoplasm; protein abundance increases in response to DNA replication stress
GO Terms: Biological Process	level 6: ribosome biogenesis level 6: translational termination level 7: mRNA processing level 8: mRNA splicing, via spliceosome level 8: negative regulation of translation level 10: negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled level 10: positive regulation of transcription elongation by RNA polymerase II
GO Terms: Molecular Function	level 4: nucleic acid binding level 5: eukaryotic initiation factor 4G binding level 5: RNA binding level 6: mRNA binding level 6: telomeric repeat-containing RNA binding level 6: RNA polymerase II complex binding level 7: double-stranded telomeric DNA binding level 8: poly(A) binding
GO Terms: Cellular Component	level 3: ribonucleoprotein complex level 3: cytoplasm level 5: nucleus level 5: cytoplasmic stress granule
External source	Open in SGD