S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Slx8p
Description	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF
GO Terms: Biological Process	level 5: cellular response to DNA damage stimulus level 6: DNA repair level 6: telomere maintenance level 8: ubiquitin-dependent protein catabolic process level 8: protein ubiquitination level 8: protein sumoylation
GO Terms: Molecular Function	level 3: transferase activity level 5: metal ion binding level 5: ubiquitin-protein transferase activity level 6: ubiquitin protein ligase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: cytoplasm level 4: endoplasmic reticulum level 4: chromosome, centromeric region level 4: kinetochore level 5: nucleus level 5: SUMO-targeted ubiquitin ligase complex level 5: chromosome
External source	Open in SGD