S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Atg18p
Description	Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (CVT) pathway; binds PtdIns(3,5)P2, PI3P and PI4P; WD-40 repeat containing protein and PROPPIN family member; relocalizes from the vacuole to cytoplasm upon DNA replication stress; mammalian homologs include: WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)
GO Terms: Biological Process	level 4: autophagy level 4: cytoplasm to vacuole transport by the Cvt pathway level 5: protein transport level 5: autophagy of nucleus level 5: autophagy of mitochondrion level 5: macroautophagy level 5: autophagy of peroxisome level 6: protein lipidation level 6: protein localization to phagophore assembly site level 6: piecemeal microautophagy of the nucleus level 6: late nucleophagy level 6: late endosome to vacuole transport level 7: vacuolar protein processing level 8: positive regulation of vacuole organization
GO Terms: Molecular Function	level 5: phosphatidylinositol-3,5-bisphosphate binding level 5: ubiquitin binding level 7: phosphatidylinositol-4-phosphate binding level 7: phosphatidylinositol-3-phosphate binding
GO Terms: Cellular Component	level 3: cytosol level 3: cell periphery level 3: phagophore assembly site level 3: membrane level 3: extrinsic component of membrane level 3: phagophore level 4: phagophore assembly site membrane level 4: endosome level 4: vacuole level 5: endosome membrane level 5: vacuolar membrane level 6: PAS complex level 7: fungal-type vacuole membrane
External source	Open in SGD