S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mon1p
Description	Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to the vacuolar membrane; required for autophagy, the CVT pathway and mitophagy; potential Cdc28 substrate
GO Terms: Biological Process	level 4: autophagy level 4: cytoplasm to vacuole transport by the Cvt pathway level 5: vesicle docking level 5: protein transport level 5: vesicle-mediated transport level 5: macroautophagy level 6: protein targeting to vacuole level 7: positive regulation of GTPase activity level 7: protein targeting to vacuolar membrane
GO Terms: Molecular Function	level 4: phosphatidylserine binding level 6: guanyl-nucleotide exchange factor activity level 7: phosphatidylinositol-5-phosphate binding level 7: phosphatidylinositol-3-phosphate binding
GO Terms: Cellular Component	level 3: cytosol level 3: Mon1-Ccz1 complex level 3: membrane level 4: endosome level 4: vacuole level 5: vacuolar membrane level 7: fungal-type vacuole membrane level 7: multivesicular body membrane
External source	Open in SGD