S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ufd1p
Description	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP)
GO Terms: Biological Process	level 6: retrograde protein transport, ER to cytosol level 6: DNA replication termination level 7: cytoplasm protein quality control by the ubiquitin-proteasome system level 7: ER-associated misfolded protein catabolic process level 7: ubiquitin-dependent ERAD pathway level 7: protein localization to vacuole level 7: positive regulation of protein localization to nucleus level 7: proteasome-mediated ubiquitin-dependent protein catabolic process level 7: negative regulation of telomerase activity level 8: ubiquitin-dependent protein catabolic process level 8: mitochondria-associated ubiquitin-dependent protein catabolic process level 8: ribosome-associated ubiquitin-dependent protein catabolic process level 9: nonfunctional rRNA decay
GO Terms: Molecular Function	level 5: polyubiquitin modification-dependent protein binding level 5: ubiquitin binding
GO Terms: Cellular Component	level 3: RQC complex level 3: cytosol level 4: replisome level 4: VCP-NPL4-UFD1 AAA ATPase complex level 5: Doa10p ubiquitin ligase complex level 5: nucleus level 6: Hrd1p ubiquitin ligase ERAD-L complex
External source	Open in SGD