S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ubr1p
Description	E3 Ub-ligase (N-recognin); recognizes and ubiquitinates N-end rule pathway substrates in complex with Rad6p; Roq1p-bound form accelerates degradation of misfolded and native ER membrane and cytosolic proteins as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; role in ER-associated protein degradation; modifies Cup9p to regulate peptide transport; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
GO Terms: Biological Process	level 5: stress-induced homeostatically regulated protein degradation pathway level 7: ubiquitin-dependent ERAD pathway level 7: cytoplasm protein quality control by the ubiquitin-proteasome system level 8: mitochondria-associated ubiquitin-dependent protein catabolic process level 8: regulation of dipeptide transport level 8: protein ubiquitination level 8: ribosome-associated ubiquitin-dependent protein catabolic process level 8: ubiquitin-dependent protein catabolic process via the N-end rule pathway level 9: protein monoubiquitination level 9: protein polyubiquitination
GO Terms: Molecular Function	level 3: transferase activity level 4: proteasome regulatory particle binding level 5: metal ion binding level 5: ubiquitin-protein transferase activity level 6: ubiquitin protein ligase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: proteasome regulatory particle, base subcomplex level 4: UBR1-RAD6 ubiquitin ligase complex level 4: ubiquitin ligase complex
External source	Open in SGD