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Gene Ontology Information

Protein Name Lag1p
Description Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication
GO Terms:
Biological Process		 level 4: lipid metabolic process external link
level 5: sphingolipid metabolic process external link
level 7: ceramide biosynthetic process external link
GO Terms:
Molecular Function		 level 3: transferase activity external link
level 6: N-acyltransferase activity external link
level 7: sphingosine N-acyltransferase activity external link
GO Terms:
Cellular Component		 level 3: membrane external link
level 4: integral component of membrane external link
level 4: acyl-CoA ceramide synthase complex external link
level 4: endoplasmic reticulum external link
level 5: endoplasmic reticulum membrane external link
External source Open in SGD external link
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