S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ssm4p
Description	Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity
GO Terms: Biological Process	level 6: retrograde protein transport, ER to cytosol level 7: ubiquitin-dependent ERAD pathway level 8: protein ubiquitination
GO Terms: Molecular Function	level 3: transferase activity level 5: ubiquitin-protein transferase activity level 5: metal ion binding level 6: ubiquitin protein ligase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: membrane level 4: nuclear envelope level 4: endoplasmic reticulum level 4: integral component of membrane level 5: nucleus level 5: endoplasmic reticulum membrane level 5: Doa10p ubiquitin ligase complex level 6: integral component of endoplasmic reticulum membrane level 6: nuclear inner membrane
External source	Open in SGD