S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mph1p
Description	3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM can make people more likely to get cancer
GO Terms: Biological Process	level 4: donor selection level 5: cellular response to DNA damage stimulus level 6: DNA repair level 6: DNA replication, Okazaki fragment processing level 7: interstrand cross-link repair level 7: recombinational repair level 8: negative regulation of strand invasion level 8: replication fork reversal level 9: double-strand break repair via synthesis-dependent strand annealing level 9: DNA duplex unwinding
GO Terms: Molecular Function	level 3: helicase activity level 3: hydrolase activity level 4: nucleotide binding level 4: DNA/RNA helicase activity level 5: 3'-5' DNA helicase activity level 5: four-way junction helicase activity level 5: DNA binding level 6: ATP binding level 6: flap-structured DNA binding level 7: four-way junction DNA binding
GO Terms: Cellular Component	level 4: chromosome, telomeric region level 5: nucleus
External source	Open in SGD