S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Srs2p
Description	DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1
GO Terms: Biological Process	level 5: DNA protection level 5: cellular response to DNA damage stimulus level 6: DNA repair level 7: recombinational repair level 8: negative regulation of DNA recombination level 8: DNA recombinase disassembly level 8: double-strand break repair via nonhomologous end joining level 9: positive regulation of endodeoxyribonuclease activity level 9: DNA duplex unwinding level 9: negative regulation of double-strand break repair via homologous recombination
GO Terms: Molecular Function	level 3: hydrolase activity level 3: helicase activity level 3: protein binding level 4: nucleotide binding level 4: enzyme activator activity level 4: DNA helicase activity level 5: DNA binding level 5: 3'-5' DNA helicase activity level 6: ATP binding
GO Terms: Cellular Component	level 5: nucleus
External source	Open in SGD