S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Bfa1p
Description	Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p; contributes to GAP activity, inactivating Tem1 by stimulating GTP hydrolysis following damage or misalignment of the mitotic spindle; functions as a guanine-nucleotide exchange inhibitor (GDI) for Tem1p; involved in multiple cell cycle checkpoint pathways that control mitotic exit; required when telomeres are damaged, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p
GO Terms: Biological Process	level 3: cell division level 3: cell cycle level 6: mitotic spindle orientation checkpoint signaling level 8: regulation of Ras protein signal transduction level 9: negative regulation of exit from mitosis
GO Terms: Molecular Function	level 5: GTPase activator activity level 6: GDP-dissociation inhibitor activity
GO Terms: Cellular Component	level 3: spindle pole level 3: cytoplasm level 4: spindle pole body level 5: Bfa1-Bub2 complex level 5: cytoskeleton level 5: mitotic spindle pole body
External source	Open in SGD