S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Irc20p
Description	E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent NHEJ pathway; controls 2-um plasmid copy number by regulating the levels of the Flp1p recombinase; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; null mutant displays increased levels of spontaneous Rad52p foci
GO Terms: Biological Process	level 6: chromatin remodeling level 6: DNA repair level 8: double-strand break repair via nonhomologous end joining level 8: protein ubiquitination level 9: double-strand break repair via synthesis-dependent strand annealing
GO Terms: Molecular Function	level 3: ATP-dependent activity, acting on DNA level 3: helicase activity level 3: hydrolase activity level 4: nucleotide binding level 4: ATP-dependent chromatin remodeler activity level 5: ubiquitin-protein transferase activity level 5: metal ion binding level 6: ATP binding level 7: zinc ion binding
GO Terms: Cellular Component	level 4: mitochondrion level 5: nucleus
External source	Open in SGD