S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Gcd7p
Description	Beta subunit of translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as negative regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog can complement yeast mutant, allows growth down-regulation of yeast gene
GO Terms: Biological Process	level 4: translational initiation level 5: translation level 7: regulation of translation level 8: regulation of translational initiation
GO Terms: Molecular Function	level 3: enzyme regulator activity level 5: translation initiation factor activity level 6: guanyl-nucleotide exchange factor activity
GO Terms: Cellular Component	level 3: cytosol level 3: eukaryotic translation initiation factor 2B complex level 4: guanyl-nucleotide exchange factor complex level 4: mitochondrion
External source	Open in SGD