S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hmg2p
Description	HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant
GO Terms: Biological Process	level 4: lipid metabolic process level 5: steroid metabolic process level 5: isoprenoid biosynthetic process level 6: steroid biosynthetic process level 6: ergosterol biosynthetic process level 6: sterol biosynthetic process level 7: coenzyme A metabolic process
GO Terms: Molecular Function	level 3: oxidoreductase activity level 5: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor level 6: hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO Terms: Cellular Component	level 3: nuclear periphery level 3: membrane level 4: proteasome complex level 4: nuclear envelope level 4: integral component of membrane level 4: endoplasmic reticulum level 5: nucleus level 5: endoplasmic reticulum membrane level 6: peroxisomal membrane
External source	Open in SGD