S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ndi1p
Description	NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy
GO Terms: Biological Process	level 4: NADH oxidation level 8: mitochondrial electron transport, NADH to ubiquinone level 8: positive regulation of apoptotic process
GO Terms: Molecular Function	level 3: oxidoreductase activity level 5: NADH dehydrogenase (ubiquinone) activity level 5: NADH dehydrogenase activity
GO Terms: Cellular Component	level 3: membrane level 4: mitochondrion level 5: mitochondrial matrix level 6: mitochondrial inner membrane
External source	Open in SGD