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Gene Ontology Information

Protein Name Ero1p
Description Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L
GO Terms:
Biological Process		 level 4: protein folding in endoplasmic reticulum external link
GO Terms:
Molecular Function		 level 3: oxidoreductase activity external link
level 4: protein-disulfide reductase activity external link
level 6: thiol oxidase activity external link
level 6: FAD binding external link
GO Terms:
Cellular Component		 level 3: membrane external link
level 4: endoplasmic reticulum external link
level 5: endoplasmic reticulum membrane external link
External source Open in SGD external link
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