S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hof1p
Description	F-BAR protein that regulates actin cytoskeleton organization; binds and bundles actin filaments, linking them to septins; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; regulates actomyosin ring dynamics and septin localization; N-term. half controls cell size and actin cable levels, while the C-term. half controls actin cable organization, inhibiting Bnr1p-mediated actin nucleation; forms axial striations/pillars at the bud neck; phosphorylated by Dbf2p
GO Terms: Biological Process	level 3: cell cycle level 3: cell division level 5: mitotic cytokinesis level 5: primary cell septum biogenesis level 5: mitotic actomyosin contractile ring maintenance level 6: cytoskeleton organization level 6: protein localization to cell division site level 6: regulation of mitotic actomyosin contractile ring contraction level 6: mitotic actomyosin contractile ring assembly level 6: actin filament bundle assembly level 8: negative regulation of actin nucleation level 8: negative regulation of formin-nucleated actin cable assembly
GO Terms: Molecular Function	level 3: protein-containing complex binding level 4: cytoskeletal protein binding level 4: phospholipid binding level 4: actin filament binding level 7: myosin II heavy chain binding
GO Terms: Cellular Component	level 3: site of polarized growth level 3: mitotic actomyosin contractile ring, proximal layer level 3: cytoplasm level 3: cell division site level 3: MIH complex level 3: HICS complex level 4: cellular bud neck septin ring level 4: plasma membrane level 4: cellular bud neck level 4: cell cortex level 5: cellular bud neck contractile ring level 5: cytoskeleton level 6: anchored component of the cytoplasmic side of the plasma membrane
External source	Open in SGD