S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Rot1p
Description	Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface
GO Terms: Biological Process	level 3: protein folding level 4: protein folding in endoplasmic reticulum level 4: 'de novo' protein folding level 4: budding cell apical bud growth level 5: establishment or maintenance of actin cytoskeleton polarity level 5: fungal-type cell wall biogenesis level 6: protein O-linked mannosylation level 6: protein N-linked glycosylation
GO Terms: Molecular Function	level 4: unfolded protein binding
GO Terms: Cellular Component	level 3: membrane level 4: integral component of membrane level 4: endoplasmic reticulum level 5: endoplasmic reticulum membrane
External source	Open in SGD