S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Dom34p
Description	Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
GO Terms: Biological Process	level 3: cell division level 3: meiotic cell cycle level 3: cell cycle level 5: translation level 6: nucleic acid phosphodiester bond hydrolysis level 7: regulation of translation level 7: RNA surveillance level 7: ribosome disassembly level 8: positive regulation of translation level 8: RNA phosphodiester bond hydrolysis, endonucleolytic level 9: nuclear-transcribed mRNA catabolic process, non-stop decay level 9: nonfunctional rRNA decay level 9: nuclear-transcribed mRNA catabolic process, no-go decay
GO Terms: Molecular Function	level 3: hydrolase activity level 5: ribosome binding level 5: nuclease activity level 5: metal ion binding level 6: endonuclease activity level 6: endoribonuclease activity
GO Terms: Cellular Component	level 3: Dom34-Hbs1 complex level 3: cytoplasm
External source	Open in SGD