S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sis1p
Description	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1
GO Terms: Biological Process	level 3: protein folding level 3: cell cycle level 4: translational initiation level 5: detection of misfolded protein level 5: chaperone cofactor-dependent protein refolding level 5: cellular response to heat level 6: misfolded protein transport level 7: nuclear protein quality control by the ubiquitin-proteasome system level 7: tRNA import into nucleus level 8: mitochondria-associated ubiquitin-dependent protein catabolic process
GO Terms: Molecular Function	level 4: unfolded protein binding level 4: chaperone binding level 4: misfolded protein binding level 5: DNA binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: cytosol level 5: nucleus level 5: cytosolic small ribosomal subunit
External source	Open in SGD