S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Nop2p
Description	rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer
GO Terms: Biological Process	level 3: methylation level 5: RNA methylation level 6: ribosome biogenesis level 6: ribosomal large subunit biogenesis level 6: RNA processing level 7: maturation of LSU-rRNA level 7: rRNA base methylation level 7: rRNA processing level 7: assembly of large subunit precursor of preribosome level 8: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO Terms: Molecular Function	level 3: transferase activity level 5: RNA binding level 5: methyltransferase activity level 6: S-adenosylmethionine-dependent methyltransferase activity level 7: rRNA (cytosine-C5-)-methyltransferase activity
GO Terms: Cellular Component	level 5: preribosome, large subunit precursor level 5: nucleus level 5: nucleolus
External source	Open in SGD