S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Tcb2p
Description	ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to bud; TCB2 has a paralog, TCB1, that arose from the whole genome duplication
GO Terms: Biological Process	level 5: endoplasmic reticulum-plasma membrane tethering level 5: lipid transport level 6: ER to Golgi ceramide transport level 6: regulation of phosphatidylinositol dephosphorylation level 6: endoplasmic reticulum membrane organization
GO Terms: Molecular Function	level 3: lipid binding
GO Terms: Cellular Component	level 3: membrane level 3: cell periphery level 3: cellular bud level 4: integral component of membrane level 4: endoplasmic reticulum level 4: plasma membrane level 5: cortical endoplasmic reticulum level 5: endoplasmic reticulum membrane
External source	Open in SGD