S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Top2p
Description	Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant
GO Terms: Biological Process	level 4: reciprocal meiotic recombination level 5: DNA metabolic process level 5: resolution of meiotic recombination intermediates level 5: chromatin organization level 5: sister chromatid segregation level 6: DNA topological change level 7: chromatin remodeling at centromere level 7: telomere maintenance via recombination level 7: DNA strand elongation involved in DNA replication level 8: regulation of mitotic recombination level 9: rRNA transcription level 10: replication fork progression beyond termination site
GO Terms: Molecular Function	level 3: isomerase activity level 4: DNA topoisomerase activity level 4: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity level 4: nucleotide binding level 5: metal ion binding level 5: DNA binding level 6: ATP binding
GO Terms: Cellular Component	level 3: DNA replication termination region level 4: mitochondrion level 4: synaptonemal complex level 5: nucleus
External source	Open in SGD