S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hrt1p
Description	RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair
GO Terms: Biological Process	level 3: cell division level 3: cell cycle level 5: cellular response to DNA damage stimulus level 5: G1/S transition of mitotic cell cycle level 6: DNA repair level 8: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process level 8: ubiquitin-dependent protein catabolic process level 8: protein ubiquitination
GO Terms: Molecular Function	level 3: protein-macromolecule adaptor activity level 4: cullin family protein binding level 5: ubiquitin-protein transferase activity level 5: metal ion binding level 6: ubiquitin protein ligase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: cytoplasm level 5: nucleus level 5: cullin-RING ubiquitin ligase complex level 6: Cul3-RING ubiquitin ligase complex level 6: Cul8-RING ubiquitin ligase complex level 6: SCF ubiquitin ligase complex
External source	Open in SGD