S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cdc33p
Description	Translation initiation factor eIF4E; mRNA cap binding protein and subunit of the mRNA cap-binding complex (eIF4F) along with eIF4A (Tif1p/Tif2p) and eIF4G (Tif4631p/Tif4632p), that mediates cap-dependent translation; required with eIF4G for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; protein abundance increases in response to DNA replication stress; human homolog EIF4E can complement the cdc33 null mutant
GO Terms: Biological Process	level 4: translational initiation level 5: regulation of cell cycle level 5: translation level 7: regulation of translation level 8: positive regulation of formation of translation preinitiation complex level 9: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO Terms: Molecular Function	level 5: RNA binding level 5: translation initiation factor activity level 7: phosphatidylinositol-3-phosphate binding level 7: RNA 7-methylguanosine cap binding level 7: mRNA cap binding
GO Terms: Cellular Component	level 3: eukaryotic translation initiation factor 4F complex level 3: cytoplasm level 5: cytoplasmic stress granule level 5: nucleus
External source	Open in SGD