S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Isu2p
Description	Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant
GO Terms: Biological Process	level 5: iron-sulfur cluster assembly level 9: cellular iron ion homeostasis level 9: tRNA wobble uridine modification
GO Terms: Molecular Function	level 1: molecular_function level 4: iron-sulfur cluster binding level 5: metal ion binding level 5: 2 iron, 2 sulfur cluster binding level 7: iron ion binding level 8: ferrous iron binding
GO Terms: Cellular Component	level 3: cytoplasm level 4: mitochondrion level 5: mitochondrial matrix
External source	Open in SGD