S.cerevisiae - Yeastract

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Gene Ontology Information

Protein Name	Mge1p
Description	Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress
GO Terms: Biological Process	level 3: protein folding level 4: protein refolding level 5: protein import into mitochondrial matrix
GO Terms: Molecular Function	level 4: unfolded protein binding level 4: chaperone binding level 4: adenyl-nucleotide exchange factor activity level 5: protein homodimerization activity
GO Terms: Cellular Component	level 4: mitochondrion level 5: PAM complex, Tim23 associated import motor level 5: mitochondrial matrix
External source	Open in SGD

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