S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Esa1p
Description	Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation
GO Terms: Biological Process	level 5: regulation of cell cycle level 5: chromatin organization level 5: cellular response to DNA damage stimulus level 6: DNA repair level 6: rDNA heterochromatin formation level 7: histone acetylation level 7: DNA-templated transcription elongation level 7: regulation of DNA-templated transcription level 8: peptidyl-lysine acetylation level 8: regulation of transcription by RNA polymerase II level 8: histone H4 acetylation level 8: negative regulation of DNA-templated transcription level 9: positive regulation of transcription by RNA polymerase II level 9: positive regulation of macroautophagy level 10: positive regulation of transcription elongation by RNA polymerase II
GO Terms: Molecular Function	level 3: transcription coregulator activity level 3: transferase activity level 4: histone binding level 5: histone acetyltransferase activity level 6: H4 histone acetyltransferase activity level 7: zinc ion binding level 8: histone crotonyltransferase activity level 8: peptide N-acetyltransferase activity
GO Terms: Cellular Component	level 3: chromatin level 7: NuA4 histone acetyltransferase complex level 8: Piccolo NuA4 histone acetyltransferase complex
External source	Open in SGD