S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Vph1p
Description	Subunit a of the vacuolar-ATPase V0 domain; encodes one of two isoforms, located in vacuolar V-ATPase complexes while STV1 encodes the second isoform and is located in Golgi and endosomal V-ATPase complexes; interaction with PI(3,5)P2 increases V-ATPase activity and contributes to hyperosmotic stress tolerance; relative distribution to the vacuolar membrane decreases upon DNA replication stress; human homolog ATP6V0A4 implicated in renal tubular acidosis, can complement yeast null mutant
GO Terms: Biological Process	level 5: polyphosphate metabolic process level 5: ion transport level 6: protein-containing complex assembly level 6: cellular hyperosmotic response level 6: protein localization to vacuolar membrane level 7: proton transmembrane transport level 11: vacuolar acidification
GO Terms: Molecular Function	level 5: proton-transporting ATPase activity, rotational mechanism level 5: ATPase binding level 5: phosphatidylinositol-3,5-bisphosphate binding
GO Terms: Cellular Component	level 3: membrane level 4: vacuole level 4: integral component of membrane level 5: membrane raft level 5: vacuolar membrane level 5: proton-transporting V-type ATPase, V0 domain level 6: fungal-type vacuole level 6: vacuolar proton-transporting V-type ATPase complex level 6: vacuolar proton-transporting V-type ATPase, V0 domain level 7: fungal-type vacuole membrane
External source	Open in SGD