S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Png1p
Description	Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease
GO Terms: Biological Process	level 6: protein deglycosylation level 6: ubiquitin-dependent glycoprotein ERAD pathway level 6: glycoprotein catabolic process level 7: protein quality control for misfolded or incompletely synthesized proteins
GO Terms: Molecular Function	level 3: hydrolase activity level 5: metal ion binding level 6: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: cytosol level 4: mitochondrion level 5: nucleus
External source	Open in SGD