Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Gene Ontology Information

Protein Name Isu1p
Description Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant
GO Terms:
Biological Process		 level 5: iron-sulfur cluster assembly external link
level 9: tRNA wobble uridine modification external link
level 9: cellular iron ion homeostasis external link
GO Terms:
Molecular Function		 level 4: ATPase activator activity external link
level 4: iron-sulfur cluster binding external link
level 5: 2 iron, 2 sulfur cluster binding external link
level 5: metal ion binding external link
level 7: iron ion binding external link
level 7: zinc ion binding external link
level 8: ferrous iron binding external link
GO Terms:
Cellular Component		 level 3: cytoplasm external link
level 4: mitochondrion external link
level 5: mitochondrial matrix external link
External source Open in SGD external link
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