S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Atg5p
Description	Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner
GO Terms: Biological Process	level 4: cytoplasm to vacuole transport by the Cvt pathway level 4: autophagy level 4: regulation of catalytic activity level 5: autophagy of nucleus level 5: protein transport level 5: autophagy of mitochondrion level 5: macroautophagy level 6: piecemeal microautophagy of the nucleus level 6: cellular response to nitrogen starvation level 6: late nucleophagy level 6: selective autophagy level 7: C-terminal protein lipidation level 7: autophagosome assembly
GO Terms: Molecular Function	level 3: hydrolase activity level 3: cargo receptor ligand activity level 4: enzyme activator activity level 5: Atg8 ligase activity
GO Terms: Cellular Component	level 3: cytoplasm level 3: cytosol level 3: phagophore assembly site level 3: membrane level 3: phagophore level 4: vacuole-isolation membrane contact site level 4: phagophore assembly site membrane level 4: Atg12-Atg5-Atg16 complex level 5: nucleus level 5: autophagosome
External source	Open in SGD