S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Rad53p
Description	DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null
GO Terms: Biological Process	level 3: cell cycle level 5: mitotic DNA damage checkpoint signaling level 5: cellular response to DNA damage stimulus level 5: protein localization level 6: phosphorylation level 6: DNA replication initiation level 6: DNA damage checkpoint signaling level 6: DNA repair level 6: protein phosphorylation level 7: peptidyl-tyrosine phosphorylation level 7: positive regulation of cellular respiration level 8: deoxyribonucleoside triphosphate biosynthetic process level 9: negative regulation of phosphorylation
GO Terms: Molecular Function	level 3: transferase activity level 4: nucleotide binding level 4: protein kinase activity level 5: kinase activity level 5: protein serine/threonine kinase activity level 5: protein serine/threonine/tyrosine kinase activity level 5: protein tyrosine kinase activity level 6: ATP binding level 8: DNA replication origin binding
GO Terms: Cellular Component	level 3: cytosol level 5: nucleus
External source	Open in SGD