S.cerevisiae - Yeastract

Locus Information

Standard Name	NCL1
Systematic Name	YBL024W
Alias	TRM4
Strain	S288c
Description	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
External sources	Open in SGD Open in KEGG

Gene Sequence Download FASTA View Seq	Sequence hidden
Promoter Sequence Download FASTA	>NCL1 YBL024W ACATGTAGTGAGCGCCGATGAAGTACTCGCAGAAAAAATAGATAATGCTGTTCCTATACC GTTCAAAACAAGGGAGGAGATAGATGCCGACGTGGAAAAAGATAGAAACGAAGGAGTTTT CGAAGGTAATATCATTCCTGATATCGACCTACGTGTAGTACACTACTACGCCACGCAGTT GTGTCTAAATAAGTATCCTCATTTGATTAACGCCTTTGATGAGACAAGCCTTATAACATT GGGTTTACTCATCGAAAAGTGGGTAAAAGACTATCTAACCAGCATCCAGACAGAACAGGG AAGGCAAAGTAAGGTAATCGGGAAGGGGCCATGCGAATTCATATCAAAACATATTGATTA TAGGCATGCGCCAGGTAATATCTGAATGTAGCAAAAACCTGGCTTTTGCGGCTGGGGAGG ATGGAAGGCTTTTGTAGGCTATTATCTACTCGAGGAAGGAACGTTAGAATATCTCCATTT TTCACGCAAAATGTGGTTCTGAGTTAATGCGTGTGCTGAAGCATAACATGAGTTATTCCC TGTATGTATGTACAGTATTTCAATTTCGCAGACCGTGGGTTACATATGTGAGCGATTAGG AAGTAGTGAAGTAATTATGGCAAGTCTAGAGGTCCGGCTGATCCCTTGCGGTGCTGAAGT AACGAAACCGCGCGCATATCTTTTGGAAGAGATTAATTTGCACTGAATTTTCAAACTTAA TTAGCGAGAAGAAGTAGATGCATTTCAATTATGCCAAAAGCAGTATTTATTACTTCTTAT AGAATATAGTATCACTTACGCTCATTTAGTGTACCCACTTACGTATTAAATGACGTACTT TTTTTTTGTCCTCTTCTGTAGCTTTTTTTCACTTTGAAAAATTTAGCGCTGAGTTCTTCC AAAGACGTCAAATCACCTACTATAGTTAAAAACATATTACTTATACTAGTTCTAACACTT CCTTTTATCTACACTGTAATCCGAAGAATACACTATAAGG
Chr coordinates	Chr II from 172534-174588